Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site |
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| Authors: | N G Seidah N J Arbatti J Rochemont A R Sheth M Chrétien |
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| Affiliation: | 1. Laboratories of Biochemical and Molecular Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada H2W 1R7;2. Laboratory of Reproduction Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Canada H2W 1R7;3. Institute for Research in Reproduction (ICMR), Bombay, India |
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| Abstract: | The complete sequence of a 94 amino acid human seminal plasma polypeptide exhibiting inhibin-like activity is presented. This molecule, called beta-inhibin, selectively and specifically suppresses the release of pituitary FSH in vivo as well as in vitro. It does not affect the secretion of LH. Such a novel acidic protein contains a very basic C-terminal segment which is easily cleaved by mild tryptic digestion. It is predicted that the FSH inhibiting activity may reside within this region of the molecule. This would imply a post Gln-Arg cleavage to release the basic C-terminal active moiety. |
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| Keywords: | β-Inhibin Pituitary FSH release Amino acid sequence Human seminal plasma |
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