The role of sialic acid in determining the survival of transcortin in the circulation |
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| Authors: | H Van Baelen G Mannaerts |
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| Affiliation: | Laboratorium voor Experimentele Geneeskunde, Rega Instituut, Katholieke Universiteit te Leuven, B-3000 Leuven, Belgium |
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| Abstract: | The effect of desialylation on the survival of human transcortin and of its ligand cortisol has been investigated using the isolated perfused rat liver preparation. In contrast with native transcortin, sialic acid-free transcortin was promptly cleared from the perfusate. The hepatic uptake was accompanied by a significant reduction of the cortisol half-life. |
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