Regulated intramembrane proteolysis takes another twist. |
| |
| Authors: | S Huppert R Kopan |
| |
| Institution: | Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA. |
| |
| Abstract: | Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
