Purification of amoebolytic substances from Bacillus licheniformis M-4 |
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| Authors: | Mariam Lebbadi Antonio Gálvez Eva Valdivia Manuel Martínez-Blueno Mercedes Maqueda |
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| Affiliation: | (1) Department of Microbiology, Faculty of Sciences, University of Granada, E-18071 Granada, Spain;(2) Department of Microbiology, Facultad de Ciencias Experimentales, Universidad de Jaén, E-23071 Jaen, Spain |
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| Abstract: | Three antibiotic peptides with amoebolytic activity have been purified from culture supernatants of Bacillus licheniformis M-4 (amoebicins m4-A, m4-B, and m4-C). They were hydrophilic peptides consisting of six different amino acids (Asp, Glu, Ser, Thr, Pro, Tyr). Their molecular weights ranged from 3,000 to 3,200. Purified amoebicins were active against human pathogenic and non-pathogenic strains of Naegleria. They also showed a broad antifungal spectrum, but a narrow antibacterial activity.Abbreviations (TFA) Trifluoroacetic acid |
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| Keywords: | Amoebicin Antibiotic Bacillus licheniformis Naegleria |
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