A conserved cleavage-site motif in chloroplast transit peptides |
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| Authors: | Y Gavel G von Heijne |
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| Affiliation: | Department of Theoretical Physics, Royal Institute of Technology, Stockholm, Sweden. |
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| Abstract: | A collection of 32 stroma-targeting chloroplast transit peptides with known cleavage sites have been analysed in terms of amino acid preferences in the vicinity of the processing site. A loosely conserved consensus motif (Val/Ile)-X-(Ala/Cys) decreases Ala is found in the majority of the transit peptides. About 30% of the sequences have a perfect match to the consensus. When such a match is found, there is a 90% probability that it specifies the correct cleavage site. |
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