Presynaptic unsilencing: searching for a mechanism |
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| Authors: | Atasoy Deniz Kavalali Ege T |
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| Institution: | Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. |
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| Abstract: | Nascent synaptic networks have a high incidence of silent synapses. In this issue of Neuron, Shen et al. show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42. |
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