Are pyrimidine dimers Non-Instructive lesions? |
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| Authors: | Christopher W Lawrence |
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| Institution: | (1) Department of Radiation Biology and Biophysics, University of Rochester Medical Center, 14642 Rochester, New York, USA |
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| Abstract: | Summary Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions. |
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