Structures of two cockroach neuropeptides assigned by fast atom bombardment mass spectrometry |
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| Authors: | Jane L. Witten,Martin H. Schaffer,Michael O&#x Shea,J.Carter Cook,Mark E. Hemling,Kenneth L. Rinehart |
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| Affiliation: | 1. Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois 60637 USA;2. Department of Psychiatry, University of Chicago, Chicago, Illinois 60637 USA;3. School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 USA |
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| Abstract: | Amino acid sequences have been assigned to two cockroach neuropeptides (Glu-Val-Asn-Phe-Ser-Pro-Asn-Trp-NH2, M I, and Glu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-NH2, M II) by application of fast atom bombardment mass spectrometry, including high resolution and linked scan (metastable) studies. The peptides show considerable homology with two other invertebrate neuropeptides, adipokinetic hormone (AKH, from a locust) and red pigment concentrating hormone (RPCH, from a prawn), whose fast atom bombardment spectra were also studied. M I and M II are thus members of a family of structurally-related invertebrate neuropeptides. |
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| Keywords: | AKH adipokinetic hormone RPCH red pigment concentrating hormone FABMS fast atom bombardment mass spectrometry HR high resolution DT's dithiothreitol/dithioerythritol HPLC high performance liquid chromatography |
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