Functional efficiency of mitochondrial membrane of rats with hepatic chronic iron overload |
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Authors: | Alberto Masini Tommaso Trenti Ezio Ventura Daniela Ceccarelli-Stanzani Umberto Muscatello |
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Institution: | 1. Istituto di: Chimica Biologica, Università di Modena, 41100 Modena, Italy;2. Istituto di: Clinica Medica III, Università di Modena, 41100 Modena, Italy;3. Istituto di: Patologia Generale, Università di Modena, 41100 Modena, Italy |
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Abstract: | The effect of hepatic iron overload, induced by two different amounts of iron, on the energy-transducing efficiency of the mitochondrial membrane has been examined. It has been found that when the epatic iron concentration is up to a threshold value mitochondria present an anomalous membrane potential. Addition of oligomycin fully restitutes it. A low content of intramitochondrial K+ is connected with this pathological condition. A relative lack of antioxidant capability is parallely exhibited by these mitochondria. A possible involvement of lipid peroxidation process in causing the membrane potential drop and the net efflux of intramitochondrial K+ is suggested. |
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