Sarcoid granulomas metabolize 25-hydroxyvitamin D<sub>3</sub><span class="math"><math><mtext>in</mtext><mtext>vitro</mtext></math></span>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Sarcoid granulomas metabolize 25-hydroxyvitamin D₃ $in vitro$

Authors:	Tetsuro Okabe Seiichi Ishizuka Michio Fujisawa Junichi Watanabe Fumimaro Takaku

Affiliation:	The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113, Japan

Abstract:	Sarcoid granulomas metabolized 25-hydroxyvitamin D₃ to two unidentified metabolites during $in vitro$ incubation. A two-step high pressure liquid chromatography system revealed two unique elution positions of these sarcoid-derived metabolites that exactly comigrated with the elution positions of 5(Z)-19-nor-10-oxo-25(OH)D₃ and 5(E)-19-nor-10-oxo-25(OH)D₃, respectively. These unique metabolites did not bind specifically to a protein receptor for 1,25(OH)₂D₃.

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