Structural and functional properties of rat liver mitochondria in hexachlorobenzene induced experimental porphyria |
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| Authors: | Alberto Masini Daniela Ceccarelli-Stanzani Tommaso Trenti Emilio Rocchi Ezio Ventura |
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| Affiliation: | 1. Istituti di Chimica Biologica, Università di Modena, 41100 - Modena - Italy;2. Istituti di Patologia Generale, Università di Modena, 41100 - Modena - Italy;3. Istituti di Clinica Medica III, Università di Modena, 41100 - Modena - Italy |
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| Abstract: | A possible link between changes in iron and porphyrin content in liver mitochondria, from rats treated with either hexachlorobenzene, iron, or hexachlorobenzene plus iron, as a function of treatment time and their structural-functional properties, has been investigated. Normal oxidative phosphorylation in mitochondria from rats treated with iron has been shown. By contrast a significant and constant uncoupling of the phosphorylative process, fully reversed by albumin, in mitochondria from rats treated with hexachlorobenzene and hexachlorobenzene plus iron has been presented. A possible involvement of pentachlorophenol in causing these abnormalities has been proposed. |
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