Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: Sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors |
| |
Authors: | Norma P. Stimler |
| |
Affiliation: | 1. Department of Medicine Wake Forest University Medical Center Winston-Salem, NC 27103 USA;2. Department of Microbiology/Immunology Wake Forest University Medical Center Winston-Salem, NC 27103 USA |
| |
Abstract: | The leukotriene-dependent component of C5adesArg-induced contractile activity on guinea pig lung parenchymal strips is inhibited by cyclooxygenase inhibitors. Indomethacin simultaneously increased leukotriene release while inhibiting both cyclooxygenase-dependent mediator release and the contractile force generated. Tissue responses to LTC4 and LTD4 are also inhibited by cyclooxygenase blockade, while contractions induced by the thromboxane A2 analog, U-46619, histamine or acetylcholine are not affected. These data indicate a functional role for cyclooxygenase metabolites in leukotriene-induced contractile responses in lung. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|