Modulation of normal myelopoiesis by retinoic acid |
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Authors: | Keiya Ozawa Noriharu Sato Akio Urabe Fumimaro Takaku |
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Affiliation: | The Third Department of Internal Medicine, University of Tokyo, Tokyo 113, Japan |
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Abstract: | The effects of retinoic acid (RA) on the proliferation and differentiation of normal myeloid progenitor cells (CFU-C) were studied. In general, RA at 10?10 to 10?6 M enhanced primary myeloid colony formation in the presence of colony-stimulating factor(s). However, macrophage colony formation was strongly inhibited by RA. This may be related to the finding that RA is able to differentiate bipotential HL-60 cells into granulocytes but not into macrophages. Moreover, secondary colony formation was always suppressed by the addition of RA to the primary cultures. It means that self-renewal capacity of CFU-C was suppressed by RA. This finding suggests that normal myelopoiesis will be suppressed eventually by RA. |
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