Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2 |
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Authors: | Redolfi E Pizzuti A Di Bacco A Susani L Labella T Affer M Montagna C Reinbold R Mumm S Vezzoni P Zucchi I |
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Affiliation: | Istituto di Tecnologie Biomediche Avanzate, CNR, Segrate, Italy. |
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Abstract: | We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci. |
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