To fit or not to fit: death decisions from morphogen fields |
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| Affiliation: | 1. Department of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland;1. Interdisciplinary Institute for Neuroscience, University of Bordeaux and CNRS, Bordeaux, France;2. Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan;1. Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, C/Dr. Aiguader 88, 08003, Barcelona, Spain;2. Instituto de Biología Funcional y Genómica (IBFG), Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, 37007 Salamanca, Spain;1. Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK;2. Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK;3. School of Biosciences, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK;4. Institute for the Physics of Living Systems, University College London, London, WC1E 6BT, UK;1. Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia;2. Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia;1. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain;2. Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain;3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain;4. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain;1. Department of Genetics and Developmental Biology, The Rappaport Faculty of Medicine and Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of Technology, 31096 Haifa, Israel;2. Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Muenster, Germany;3. Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland;4. Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland;5. Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland |
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| Abstract: | The transforming growth factor-β (TGF-β)-type morphogens are conserved throughout the animal kingdom. TGF-β-type molecules form spatial concentration gradients whose length scales with the size of growing, developing organs. Scaling of these morphogens can also be mediated by death, adjusting the size of the tissue to the range of the gradient. Death-mediated scaling might provide a molecular toolbox exploited by cancer cells. |
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