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Chemical modulation of microtubule structure through the laulimalide/peloruside site
Affiliation:1. Centro de Investigaciones Biológicas Margarita Salas - Consejo Superior de Investigaciones Científicas, Madrid 28040, Spain;2. Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences - ETH Zurich, Zürich 8093, Switzerland;3. Department of Organic and Macromolecular Chemistry, Ghent University, Gent 9000, Belgium;4. Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK;5. ALBA Synchrotron, CELLS, Cerdanyola del Vallés 08290, Spain;6. Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen 5232, Switzerland;7. Ferrier Research Institute, University of Wellington, Lower Hutt 5010, New Zealand;8. University of Basel, Biozentrum, Basel 4056, Switzerland;9. Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, Tokyo 192-0393, Japan;10. Department of Biomedical Sciences and Associated Unit IQM-UAH, Universidad de Alcalá, Alcalá de Henares 28805, Spain
Abstract:
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  • Keywords:microtubule-stabilizing agents  peloruside  laulimalide  tubulin  microtubules
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