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Substrate-binding guides individual melibiose permeases MelB to structurally soften and to destabilize cytoplasmic middle-loop C3 |
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| Institution: | 1. Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, 4058 Basel, Switzerland;2. Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA |
| Abstract: |  |
| Keywords: | melibiose permease MelB functional states mechanical stability substrate binding co-substrate binding structural destabilization stability of C3 loop population of states atomic force microscopy single-molecule force spectroscopy |
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