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Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity
Affiliation:1. Department of Anesthesiology, The Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO, USA;2. Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China;3. Visceral Neurophysiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;4. Neurogastroenterology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;5. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei, People’s Republic of China
Abstract:
Keywords:visceral mechanosensitivity  hypersensitivity  Piezo2 channels  TRPV1-lineage nociceptors  irritable bowel syndrome  partial colon obstruction
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