谷氨酰胺磷酸核糖焦磷酸转酰胺酶研究进展

谷氨酰胺磷酸核糖焦磷酸转酰胺酶是生物．体内嘌呤产物合成途径的关键酶，负责催化全合成途径的第一步反应。肌苷属于嘌呤核苷，是食品和医药行业广泛应用的重要产品。谷氨酰胺磷酸核糖焦磷酸转酰胺酶在肌苷的生物合成途径中起重要调节作用，对其深入研究将有助于提高肌苷的产量，对工业化生产有重大意义。本从谷氨酰胺磷酸核糖焦磷酸转酰胺酶的属性、功能、结构和基因表达与调控方面对其做了介绍，为肌苷产量的提高工作奠定了基础。

Advanced studies on glutamine phosphoribosylpyrophosphate amidotransferase

Glutamine phosphoribosylpyrophosphate amidotransferase(GPATase) is the key regulatory enzyme in purine biosynthesis. It catalyses the first step in de novo pathway. As a purine nucleoside, inosine is an important product in food and medicine industry. GPATase plays an essential role in the pathways of inosine biosynthesis. Research on it will be helpful to the increasing of inosine production, and may take important development in industry. Its classification, function, structure, gene expression and regulation are mainly introduced in this paper. This knowledge is the basis of the further work for increasing the inosine production.