Divergent evolution and purifying selection of the flaA gene sequences in Aeromonas |
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Authors: | Maribel Farfán David Miñana-Galbis M Carmen Fusté J Gaspar Lorén |
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Institution: | 1. Departament de Microbiologia i Parasitologia Sanitàries, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028, Barcelona, Spain
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Abstract: | Background The bacterial flagellum is the most important organelle of motility in bacteria and plays a key role in many bacterial lifestyles,
including virulence. The flagellum also provides a paradigm of how hierarchical gene regulation, intricate protein-protein
interactions and controlled protein secretion can result in the assembly of a complex multi-protein structure tightly orchestrated
in time and space. As if to stress its importance, plants and animals produce receptors specifically dedicated to the recognition
of flagella. Aside from motility, the flagellum also moonlights as an adhesion and has been adapted by humans as a tool for
peptide display. Flagellar sequence variation constitutes a marker with widespread potential uses for studies of population
genetics and phylogeny of bacterial species. |
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Keywords: | |
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