Chromosomal mapping of the mouse IL-4 and human IL-5 genes |
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| Authors: | M Takahashi M C Yoshida H Satoh J Hilgers Y Yaoita T Honjo |
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| Institution: | Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | We mapped the mouse interleukin (IL)-4 gene on chromosome 11 by restriction fragment length polymorphism using recombinant inbred mouse strains. The human IL-5 gene was mapped on chromosome 5q 23.3-31.1 by in situ hybridization. Because the granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-3 genes were previously mapped on mouse chromosome 11 (within a 230-kb region) and human chromosome 5, the IL-4 and IL-5 genes are likely to cluster on the same chromosomes with the GM-CSF and IL-3 genes in both species. |
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