DNA-RNA hybrid secondary structures |
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| Authors: | S Arnott R Chandrasekaran R P Millane H S Park |
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| Affiliation: | 1. CNRS Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Université de Paris Cité, 13 rue Pierre et Marie Curie, 75005 Paris, France;2. PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France;1. Fakulta riadenia a informatiky, Žilinská Univerzita v Žiline, Univerzitná 8215/1, Žilina, 010 26, Slovakia;2. Mathematical Institute of Slovak Academy of Sciences, Ďumbierska 1, Banská Bystrica, 974 11, Slovakia;3. University of California, Davis, Linguistics Department, 469 Kerr Hall, One Shields Avenue, Davis, CA 95616, USA |
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| Abstract: | DNA-RNA and DNA-DNA duplexes are even more polymorphic than observed previously. DNA-RNA hybrids can have secondary structures like A-DNA or A-RNA, but double helices of the synthetic DNA-RNA hybrids poly(dA) X poly(rU) and poly(dI) X poly(rC), respectively, form 11-fold and 10-fold double-helical structures in which the two chains have quite different conformations. Extensive X-ray fiber diffraction analyses show that in both structures the DNA chains have C-2'-endo-puckered furanose rings, while the anti-parallel RNA chains have C-3'-endo-puckered rings. The bidirectional properties of such duplexes may be important in the transfer of biological information from nucleic acids. |
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