Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats |
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Authors: | Ayano Katagiri Masamichi Shinoda Kuniya Honda Akira Toyofuku Barry J Sessle Koichi Iwata |
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Institution: | 1. Neuroscience Program, Washington University School of Medicine, St. Louis, MO, USA 2. Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA 3. Department of Anesthesiology, Washington University Pain Center, St. Louis, MO, USA 4. Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA 5. Saint Louis University School of Medicine, St. Louis, MO, USA 6. Division of Urologic Surgery, Department of Surgery, St. Louis Veterans Affairs Medical Center, Washington University School of Medicine, St. Louis, MO, USA 7. Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, St Louis, MO, 63110, USA
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Abstract: | Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications. The etiology is unknown, however evidence suggests that nervous system sensitization contributes to enhanced pain in IC/PBS. In particular, central nervous system plasticity of glutamatergic signaling involving NMDA and metabotropic glutamate receptors (mGluRs) has been implicated in a variety of chronic pain conditions. Here, we test the hypothesis that mGluR5 mediates both non-inflammatory and inflammatory bladder pain or nociception in a mouse model by monitoring the visceromotor response (VMR) during graded bladder distention. Results Using a combination of genetic and pharmacologic approaches, we provide evidence indicating that mGluR5 is necessary for the full expression of VMR in response to bladder distention in the absence of inflammation. Furthermore, we observed that mice infected with a uropathogenic strain of Escherichia coli (UPEC) develop inflammatory hyperalgesia to bladder distention, and that the selective mGluR5 antagonist fenobam N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl) urea], reduces the VMR to bladder distention in UPEC-infected mice. Conclusions Taken together, these data suggest that mGluR5 modulates both inflammatory and non-inflammatory bladder nociception, and highlight the therapeutic potential for mGluR5 antagonists in the alleviation of bladder pain. |
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