Synthesis of new pryridyl alcohols and their use as catalysts in the asymmetric addition of diethylzinc to aldehydes. |
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| Authors: | Qianyong Xu Xiaoming Wu Xinfu Pan Albert S C Chan Teng-Kuei Yang |
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| Affiliation: | Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China. |
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| Abstract: | Optically active new pyridyl alcohols 1-4, which can be easily synthesized by the reaction of (+)-camphor or (-)-menthone with lithiated pyridine derivatives, were applied as chiral ligands in the asymmetric addition of diethylzinc to aldehydes. Good yields with up to 94.0% enantiomeric excesses were observed in these reactions. |
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| Keywords: | asymmetric addition pyridyl alcohols (+)‐camphor (−)‐menthone diethylzinc |
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