Time Course of Postnatal Distribution of Doublecortin Immunoreactive Developing/Maturing Neurons in the Somatosensory Cortex and Hippocampal CA1 Region of C57BL/6 Mice |
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| Authors: | Dae?Young?Yoo Ki-Yeon?Yoo Ji?Won?Choi Woosuk?Kim Choong?Hyun?Lee Jung?Hoon?Choi Jeong?Ho?Park Email author" target="_blank">Moo-Ho?WonEmail author Email author" target="_blank">In?Koo?HwangEmail author |
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| Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Oral Anatomy, School of Dentistry, Gangneung-Wonju National University, Gangneung, 210-702, South Korea;(3) Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(4) Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(5) Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(6) Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon, 305-719, South Korea; |
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| Abstract: | In this study, we observed neuroblast differentiation in the somatosensory cortex (SSC) and hippocampal CA1 region (CA1),
which is vulnerable to oxidative stress, of the mouse at various early postnatal days (P) 1, 7, 14, and 21 using doublecortin
(DCX, a marker for neuroblasts). Cresyl violet and NeuN (Neuronal Nuclei) staining showed development of layers as well as
neurons in the SSC and CA1. At P1, DCX-positive neuroblasts expressed strong DCX immunoreactivity in both the SSC and CA1.
Thereafter, DCX immunoreactivity was decreased with time. At P7, many DCX-immunoreactive neuroblasts were well detected in
the SSC and CA1. At P14, some DCX-positive neuroblasts were found in the SSC and CA1: The immunoreactivity was weak. At P21,
DCX immunoreactivity was hardly found in cells in the SSC and CA1. These results suggest that DCX-positive neuroblasts were
significantly decreased in the mouse SSC and CA1 from P14. |
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