Receptors and signaling mechanisms for B-lymphocyte activation, proliferation and differentiation - Insights from both in vivo and in vitro approaches |
| |
Authors: | Ravi Maddaly Govind Pai |
| |
Affiliation: | Faculty of Biomedical Sciences, Technology and Research, Department of Human Genetics, Sri Ramachandra University, Porur, Chennai 600 116, Tamil Nadu, India |
| |
Abstract: | During the last three decades, a number of B-lymphocyte specific surface antigens have been defined some of which may also show activation/differentiation specific expression. Here, we review the various signaling events and the receptor-ligand interactions for B-cell development, activation and differentiation. Our discussion and presentation include reviewing the in vivo and in vitro mechanisms. Focus is on the experiments that give us valuable insights into the B cell signaling mechanisms in vitro. Three significant pathways in B-cell development - c-Kit, FLT-3 and IL-7 signaling pathways are elucidated upon. Both antigen dependent and antigen independent mechanisms of B cell stimulation are also reviewed. |
| |
Keywords: | BCGF, B cell growth factor BCR, B-cell receptor BMT, bone marrow transplantation CD, clusters of differentiation CLP, common lymphoid progenitor Con-A, Concanavalin-A FLK-2, fetal liver kinase-2 FLT3, fms-like tyrosine kinase 3 GTPase, Ras guanosine triphosphatase HSC, hematopoietic stem cell IFN, interferon IgD, immunoglobulin D IgG, immunoglobulin G IgM, immunoglobulin M IL, interleukin IVI, in vitro immunizations LPS, lipopolysaccharides MAb, monoclonal antibodies MAP Kinase, mitogen-activated protein kinase pathway M-CSF, macrophage colony-stimulating factor MDP, N-acetylmuramyl- smallcaps" >l-alanyl- smallcaps" >d-isoglutamine MF, mitogenic factors MHC, major histocompatibility complex PDGF-R, platelet-derived growth factor PG, peptidoglycans PHA, phytoheamoagglutin PI3K, phosphoinositide-3 kinase PLC-γ 1, phospholipase C-γ 1 pre-B, precursor-B pro-B, progenitor-B PWM, poke weed mitogen Rag, recombination-activating gene RBC, red blood cells SF, steel factor STK-1, human stem cell kinase-1 TCR, T-cell receptor TD antigen, T-dependent antigen TI antigen, T-independent antigen TLR, toll-like receptors TM, transmembrane TRF, T cell replacing factor |
本文献已被 ScienceDirect 等数据库收录! |
|