An efflux pump is involved in secretion of newly synthesized siderophore by Pseudomonas aeruginosa |
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| Authors: | Hannauer Mélissa Yeterian Emilie Martin Lois W Lamont Iain L Schalk Isabelle J |
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| Affiliation: | a Métaux et Microorganismes: Chimie, Biologie et Applications, FRE 3211, ESBS, Blvd Sébastien Brant, BP 10412, F-67413 Illkirch, Strasbourg, France
b Department of Biochemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand |
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| Abstract: | Pseudomonas aeruginosa secretes the fluorescent siderophore, pyoverdine (PVD), to enable iron acquisition. Epifluorescence microscopy and cellular fractionation were used to investigate the role of an efflux pump, PvdRT-OpmQ, in PVD secretion. Bacteria lacking this efflux pump accumulated PVD, or a fluorescent precursor, in the periplasm, due to their inability to efficiently secrete into the media newly synthesized PVD. PvdRT-OpmQ is only the second system identified for secretion of newly synthesized siderophores by Gram negative bacteria. |
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| Keywords: | PVD, pyoverdine PVDI, PVD produced by Pseudomonas aeruginosa strain PAO1 |
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