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Fission yeast telomeres forecast the end of the crisis |
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| Authors: | Pierre-Marie Dehé |
| Institution: | Telomere Biology Laboratory, Cancer Research UK, London WC2A 3PX, United Kingdom |
| Abstract: | Recent years have placed fission yeast at the forefront of telomere research, as this organism combines a high level of conservation with human telomeres and precise genetic manipulability. Here we highlight some of the latest knowledge of fission yeast telomere maintenance and dysfunction, and illustrate how principles arising from fission yeast research are raising novel questions about telomere plasticity and function in all eukaryotes. |
| Keywords: | ATM ataxia telangiectasia mutated (Tel1 in budding yeast) ATR ATM and Rad3 Related ChIP chromatin immuno-precipitation DDR DNA damage response DSB double strand break dsDNA double stranded DNA HR homologous recombination NHEJ non-homologous end-joining MRN MRE11/RAD50/NBS1 OB-fold oligonucleotide/oligosaccharide-fold Polα and δ DNA polymerase α and δ (lagging strand polymerases) Polε DNA polymerase ε (leading strand polymerase) ssDNA single stranded DNA SSA single strand annealing STE sub-telomeric-element TPE telomere position effect |
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