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Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11 |
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| Authors: | Stevenson Nigel J McFarlane Cheryl Ong Seow Theng Nahlik Krystyna Kelvin Alyson Addley Mark R Long Aideen Greaves David R O'Farrelly Cliona Johnston James A |
| Institution: | a Centre for Infection & Immunity, School of Medicine, Dentistry & Biomedical Science, Queen’s University of Belfast, United Kingdom b School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland c Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland d Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom |
| Abstract: | Suppressors of cytokine signalling (SOCS) proteins regulate signal transduction, but their role in responses to chemokines remains poorly understood. We report that cells expressing SOCS1 and 3 exhibit enhanced adhesion and reduced migration towards the chemokine CCL11. Focal adhesion kinase (FAK) and the GTPase RhoA, control cell adhesion and migration and we show the presence of SOCS1 or 3 regulates expression and tyrosine phosphorylation of FAK, while also enhancing activation of RhoA. Our novel findings suggest that SOCS1 and 3 may control chemotaxis and adhesion by significantly enhancing both FAK and RhoA activity, thus localizing immune cells to the site of allergic inflammation. |
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