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The small RNA expression profile of the developing murine urinary and reproductive systems |
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| Authors: | Aguilar Ana Laura Gutierrez Piskol Robert Beitzinger Michaela Zhu Jia Yun Kruspe Dagmar Aszodi Attila Moser Markus Englert Christoph Meister Gunter |
| Affiliation: | a Laboratory of RNA Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany b University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany c Department of Biology II, Section of Evolutionary Biology, University of Munich, Grosshadernerstrasse 2, 82152 Planegg Martinsried, Germany d Leibniz Institute for Age Research - Fritz Lipmann Institute e.V. (FLI), Beutenbergstrassse 11, 07745 Jena, Germany e Department of Molecular Medicine, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany |
| Abstract: | microRNAs (miRNAs) are small non-coding RNAs with fundamental roles in the regulation of gene expression. miRNAs assemble with Argonaute (Ago) proteins to miRNA-protein complexes (miRNPs), which interact with distinct binding sites on mRNAs and regulate gene expression. Specific miRNAs are key regulators of tissue and organ development and it has been shown in mammals that miRNAs are also involved in the pathogenesis of many diseases including cancer. Here, we have characterized the miRNA expression profile of the developing murine genitourinary system. Using a computational approach, we have identified several miRNAs that are specific for the analyzed tissues or the developmental stage. Our comprehensive miRNA expression atlas of the developing genitourinary system forms an invaluable basis for further functional in vivo studies. |
| Keywords: | microRNA Kidney Testis Ovary Gene silencing |
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