Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells

Authors:	Sato Sei-ichi Inoue Hiroki Kogure Takeshi Tagaya Mitsuo Tani Katsuko

Affiliation:	School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

Abstract:	Mammals have three members of the intracellular phospholipase A₁ protein family (phosphatidic acid preferring-phospholipase A₁, p125, and KIAA0725p). In this study, we showed that KIAA0725p is localized in the Golgi, and is rapidly cycled between the Golgi and cytosol. Catalytic activity is important for targeting of KIAA0725p to Golgi membranes. RNA interference experiments suggested that KIAA0725p contributes to efficient membrane trafficking from the Golgi apparatus to the plasma membrane, but is not involved in brefeldin A-induced Golgi-to-endoplasmic reticulum retrograde transport. Structured summary MINT-8019765: KIAA0725 (uniprotkb:O94830) and Beta-COP (uniprotkb:P53618) colocalize (MI:0403) by fluorescence microscopy (MI:0416)MINT-8019775: KIAA0725 (uniprotkb:O94830) and GM130 (uniprotkb:Q5PXD5) colocalize (MI:0403) by fluorescence microscopy (MI:0416)

Keywords:	Phospholipase A₁ Golgi apparatus Vesicular transport Brefeldin A
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