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Activation of the NLRP3 inflammasome by intracellular poly I:C |
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| Authors: | Rajan Jayant V Warren Sarah E Miao Edward A Aderem Alan |
| Institution: | a Institute for Systems Biology, Seattle, WA 98103, United States b Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, United States c Department of Immunology, University of Washington, Seattle, WA 98195, United States |
| Abstract: | Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome. |
| Keywords: | Inflammasome Poly I:C RNA virus IL-1β |
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