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Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription |
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| Authors: | Subramaniam Ramachandran Dai Shida Xianjun Fang Sheldon Milstien Sarah Spiegel |
| Affiliation: | a Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States b Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, United States c Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA, United States |
| Abstract: | |
| Keywords: | C/EBPβ, CCAAT/enhancer-binding protein β EGF, epidermal growth factor EGFR, epidermal growth factor receptor ERK1/2, extracellular-signal-regulated kinase 1/2 LPA, lysophosphatidic acid QPCR, quantitative real-time polymerase chain reaction siRNA, small interfering RNA S1P, sphingosine-1-phosphate SphK1, sphingosine kinase type 1 |
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