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Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain |
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| Authors: | Arai Munehito Dyson H Jane Wright Peter E |
| Institution: | a Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States b Protein Design Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan c Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan |
| Abstract: | |
| Keywords: | CD circular dichroism CBP CREB binding protein CREB cyclic-AMP response element binding protein HSQC heteronuclear single quantum correlation ITC isothermal titration calorimetry MLL mixed-lineage leukemia protein MRE mean residue ellipticity pKID phosphorylated kinase-inducible domain of CREB S D standard deviation SVD singular value decomposition TAD transactivation domain |
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