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Hem-1: putting the "WAVE" into actin polymerization during an immune response |
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| Authors: | Park Heon Chan Maia M Iritani Brian M |
| Institution: | The Department of Comparative Medicine, University of Washington, Seattle, WA 98195-7190, USA |
| Abstract: | Most active processes by immune cells including adhesion, migration, and phagocytosis require the coordinated polymerization and depolymerization of filamentous actin (F-actin), which is an essential component of the actin cytoskeleton. This review focuses on a newly characterized hematopoietic cell-specific actin regulatory protein called hematopoietic protein-1 Hem-1, also known as Nck-associated protein 1-like (Nckap1l or Nap1l)]. Hem-1 is a component of the “WAVE WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein]” complex, which signals downstream of activated Rac to stimulate F-actin polymerization in response to immuno-receptor signaling. Genetic studies in cell lines and in mice suggest that Hem-1 regulates F-actin polymerization in hematopoietic cells, and may be essential for most active processes dependent on reorganization of the actin cytoskeleton in immune cells. |
| Keywords: | Cdc42 cell division control protein 42 Rho Ras homolog gene family member Rac Ras-related C3 botulinum toxin substrate Tiam1 T-cell lymphoma invasion and metastasis 1 Bcr breakpoint cluster region IL Interleukin Sra-1 specifically Rac associated 1 HSPC300 hematopoietic stem/progenitor cell protein 300 Cdk5 cell division protein kinase 5 MAPK mitogen-activated protein kinase IRSp53 insulin receptor tyrosine kinase substrate p53 Nap1 Nck-associated protein 1 HL-60 human promyelocytic leukemia cells-60 Lin lineage TNF tumor necrosis factor MIP macrophage inflammatory proteins NF-κB nuclear factor-kappaB Rag recombinase activating gene Syk spleen tyrosine kinase cAMP/cGMP cyclic adenosine monophosphate/cyclic guanosine monophosphate |
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