Collaboration and competition between DNA double-strand break repair pathways |
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Authors: | Elizabeth M. Kass |
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Affiliation: | Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA |
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Abstract: | DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair. The two major pathways involved in the repair of double-strand breaks in eukaryotic cells are non-homologous end joining and homologous recombination. Numerous factors affect the decision to repair a double-strand break via these pathways, and accumulating evidence suggests these major repair pathways both cooperate and compete with each other at double-strand break sites to facilitate efficient repair and promote genomic integrity. |
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Keywords: | Double-strand break DNA repair Non-homologous end joining Homologous recombination Single-strand annealing |
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