Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway |
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| Authors: | Bae Yoonhee Choi Dongwon Rhim Hyangshuk Kang Seongman |
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| Affiliation: | a Graduate School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea
b Research Institute of Molecular Genetics, College of Medicine, Catholic University of Korea, Seoul 137-701, Republic of Korea |
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| Abstract: | Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death.Structured summaryMINT-8045218, MINT-8045231: Hip2 (uniprotkb:P61086) physically interacts (MI:0915) with cyclin-B1 (uniprotkb:P14635) by pull down (MI:0096) |
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| Keywords: | Hip2 Cyclin B1 Ubiquitination Apoptosis |
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