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Pre-clustered TCR complexes |
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| Authors: | Eszter Molnár Sumit Deswal Wolfgang WA Schamel |
| Institution: | a Department of Molecular Immunology, Max Planck-Institute of Immunobiology and Institute of Biology III, Faculty of Biology, University of Freiburg, Stübeweg 51, 79108 Freiburg, Germany b Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Germany c Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Germany d Centre for Chronic Immunodeficiency (CCI), Freiburg University Medical Centre, Germany |
| Abstract: | The T-cell antigen receptor (TCR) is a multisubunit transmembrane complex that mediates the antigen-specific activation of T cells. Using a variety of techniques, several research groups have shown that TCRs are at least partially pre-clustered before antigen binding. These new findings are contradictory to the “classical” view, according to which TCRs are randomly distributed on the cell surface and only associate upon antigen binding. In this review we try to answer the following questions: What are the experimental evidences for the existence of pre-clustered TCRs? How can the TCR pre-clusters be activated upon antigen binding? Which functional consequences for T-cell activation arise from the pre-clustering of TCRs. |
| Keywords: | TCR Stoichiometry Protein cluster Signaling model |
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