Cloning of a novel homeobox (NK-7.1) containing gene,DmHboxNK-7.1, from Drosophila melanogaster |
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| Authors: | Sakoyama Yasuhiko Mizuta Ikuko Fukunaga Akihiro Michinomae Masanobu Smith Phillip R |
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| Affiliation: | (1) Department of Genetics, Osaka University Medical School, Osaka, Japan;(2) Clinical Research Center, Utano National Hospital, Kyoto, Japan;(3) Department of Nursing, College of Nursing, Osaka City University, Osaka, Japan;(4) Department of Biology, Faculty of Science, Konan University, Kobe, Japan |
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| Abstract: | We have cloned a novel Drosophila melanogaster homeobox (Hbox) containing gene, NK-7.1 (Dm.HboxNK-7.1), which is located at 88B3 on the chromosome map, and is 1.5 kb downstream of the spn-B gene. The newly identified gene is expressed at high levels in the embryo, is switched off during larval and pupal stages, and is expressed again in the adult. The Hbox is highly similar to NK-1/S59 (Drosophila) and NK-3/bap (Drosophila). The amino acid (aa) identity ratios (%) were 58 between NK-7.1 and NK-1/S59, and between NK-7.1 and NK-3/bap. The other characteristic structures are the presence of homopolymeric aa stretches consisting of Q, N, and E. |
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| Keywords: | Drosophila ems E5 spn-B RT-PCR homeodomain opa repeat |
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