Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents |
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| Authors: | Gwaltney S L Imade H M Barr K J Li Q Gehrke L Credo R B Warner R B Lee J Y Kovar P Wang J Nukkala M A Zielinski N A Frost D Ng S C Sham H L |
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| Institution: | Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. stephen.gwaltney@abbott.com |
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| Abstract: | Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents. |
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