Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni |
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| Authors: | Thiago A Pereira Guilherme Vaz de Melo Trindade Elisangela Trindade Santos Fausto EL Pereira Márcia Maria de Souza |
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| Institution: | 1. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA;2. Laboratory of Experimental Pathology, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, BA, Brazil;3. Physiology, School of Medicine, National University of Ireland, Galway, Galway, Ireland;4. Vila Velha University, Vila Velha, ES, Brazil |
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| Abstract: | The pathogenesis of schistosomiasis and the mechanism of disease regression after Praziquantel pharmacotherapy are not fully elucidated. Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), and systemic OPN levels strongly correlate with disease severity, suggesting its use as a potential morbidity biomarker. In this study, we investigated the impact of Praziquantel use on systemic OPN levels and on liver collagen deposition in chronic murine schistosomiasis. Praziquantel treatment significantly reduced systemic OPN levels and liver collagen deposition, indicating that OPN could be a reliable tool for monitoring PZQ efficacy and fibrosis regression in murine schistosomiasis. |
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| Keywords: | Schistosomiasis Osteopontin Praziquantel Liver fibrosis Fibrosis regression |
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