| 心肺复苏后大鼠神经元氧自由基的变化及卡尼汀的干预作用 |
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| 引用本文： | 张雷,林兆奋,李新宇,周新.心肺复苏后大鼠神经元氧自由基的变化及卡尼汀的干预作用[J].现代生物医学进展,2010,10(6). |
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| 作者姓名： | 张雷 林兆奋 李新宇 周新 |
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| 作者单位： | 1. 兰州军区乌鲁木齐总医院急救中心,新疆,乌鲁木齐,830000
2. 第二军医大学附属长征医院急救科,上海,200433 |
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| 摘 要： | 目的:研究心肺复苏后大鼠脑细胞氧自由基的改变及卡尼汀的干预作用。方法:本实验采用窒息合并冰氯化钾停跳液致大鼠心跳骤停5min后开始心肺复苏的动物模型,SD大鼠88只,随机分为11组:对照组(假手术组)、复苏后3、12、24、48、72h组(每组8只),复苏后卡尼汀干预3、12、24、48、72h组(每组8只)。各组抽静脉血测定血液中丙二醛(MDA)含量及超氧化物歧化酶(SOD)活力。结果:心跳骤停/心肺复苏后各组大鼠血清中MDA含量较对照组显著升高(p<0.05),SOD活力显著降低(P<0.05)。使用卡尼汀干预后,血清MDA含量显著降低(P<0.05),SOD活力基本正常(P<0.05)。结论:心肺复苏后大鼠氧自由基产生增多,清除减少;卡尼汀干预后,氧自由基产生减少。卡尼汀对心肺复苏后大鼠具有保护作用。
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| 关 键 词： | 卡尼汀 心肺复苏 氧自由基 |
Changes in oxygen free radical of plasma in Rats after Cardiopulmonary Resuscitation and the intervention effect of carnitine |
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| ZHANG Lei,LIN Zhao-fen,LI Xin-yu,ZHOU Xin.Changes in oxygen free radical of plasma in Rats after Cardiopulmonary Resuscitation and the intervention effect of carnitine[J].Progress in Modern Biomedicine,2010,10(6). |
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| Authors: | ZHANG Lei LIN Zhao-fen LI Xin-yu ZHOU Xin |
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| Institution: | ZHANG Lei1,LIN Zhao-fen2,LI Xin-yu1,ZHOU Xin1 (1 Department of Emergency Medicine,Urumqi General Hospital of Lan Zhou Military Comm,,830000,Urumqi,China,2 Department of Emergency Medicine,Changzheng Hospital,the Second Military Medical University,Shanghai,China) |
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| Abstract: | Objective: To observe Changes in oxygen free radical of plasma in Rats after Cardiopulmonary Resuscitation(CPR),and to observe the intervention effect of carnitine on these changes.Methods: Cardiac arrest was induced by asphyxiation and ice-cold 0.5M KCl and resuscitation was started in five minutes after arrest.Eighty-eight SpragueDawley rats were divided into 11 groups randomly: sham (control group);after cardiopulmonary resuscitation rats were allowed to reperfuse spontaneously for 3 hours,12 hours,24 ho... |
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| Keywords: | cardiopulmonary resuscitation oxygen free radical Carnitine |
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