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The effects of busulphan on the chromosomes of normal human lymphocytes
Authors:J R Honeycombe
Institution:Department of Cytogenetics and Immunogenetics, Institute of Cancer Research, Royal Marsden Hospital, London, S.W.3 Great Britain
Abstract:In vitro exposure of human lymphocytes to busulphan (BUS) produced an increase in chromosome aberrations and in sister-chromatid exchange (SCE) frequency. The distribution of chromosome breaks throughout the karyotype was non-random and they occurred mainly in the G-negative bands. Certain bands had a marked susceptibility to BUS and comparisons with the human chromosome-break distributions reported for a number of drugs revealed that some of these bands were equally susceptible to other alkylating agents. Both the number of chromosome gaps and breaks and the SCE frequency increased with BUS concentration, but only the SCE dose--response was a clearly defined linear relationship. Therefore a standard SCE dose--response curve was constructed for future comparison with the results of similar investigations of patients on BUS therapy.
Keywords:BUdR  bromodeoxyuridine  BUS  busulphan (1  4-dimethanesulphonyloxybutane)  CML  chronic myeloid leukaemia  ECHH  epichlorohydrin  SCE  sister-chromatid exchange
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