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Damage-induced chromatome dynamics link Ubiquitin ligase and proteasome recruitment to histone loss and efficient DNA repair
Authors:Kiran Challa  Christoph D. Schmid  Saho Kitagawa  Anaïs Cheblal  Vytautas Iesmantavicius  Andrew Seeber  Assaf Amitai  Jan Seebacher  Michael H. Hauer  Kenji Shimada  Susan M. Gasser
Affiliation:1. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland;2. Faculty of Natural Sciences, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland;3. Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Aramaki Aza Aoba 468-1, Aoba-ku, Sendai, 981-8545, Japan;4. Center for Advanced Imaging, Northwest Building, 52 Oxford St., Harvard University, Cambridge, MA 02138, USA;5. Department of Chemical Engineering, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA;6. The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
Abstract:
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  • Keywords:Histone degradation  Ubiquitin ligases  proteasome  Chromatin proteomics  DNA damage response  INO80  HMGB1/NHP6  DNA dynamics  homologous recombination
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