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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis,but Not of Primary Breast Tumors,to mTORC1 Inhibition
Authors:Gianmarco Rinaldi  Erica Pranzini  Joke Van Elsen  Dorien Broekaert  Cornelius M. Funk  Mélanie Planque  Ginevra Doglioni  Patricia Altea-Manzano  Matteo Rossi  Vincent Geldhof  Shao Thing Teoh  Christina Ross  Kent W. Hunter  Sophia Y. Lunt  Thomas G.P. Grünewald  Sarah-Maria Fendt
Affiliation:1. Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium;2. Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium;3. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy;4. Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Strasse 36, 80337 Munich, Germany;5. Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany;6. Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany;7. Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium;8. Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium;9. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA;10. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;11. Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA;12. Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
Abstract:
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  • Keywords:metastasis formation  mTORC1  pyruvate  serine biosynthesis  PHGDH  MCT2  breast cancer  α-ketoglutarate  lung environment
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