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CARM1 regulates replication fork speed and stress response by stimulating PARP1
Authors:Marie-Michelle Genois  Jean-Philippe Gagné  Takaaki Yasuhara  Jessica Jackson  Sneha Saxena  Marie-France Langelier  Ivan Ahel  Mark T. Bedford  John M. Pascal  Alessandro Vindigni  Guy G. Poirier  Lee Zou
Affiliation:1. Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;2. Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, QC G1V 0A6, Canada;3. CHU de Québec Research Center, CHUL Pavilion, Oncology Axis, Québec City, Québec G1V 4G2, Canada;4. Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA;5. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada;6. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;7. Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA;8. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Abstract:
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  • Keywords:CARM1  replication fork  fork reversal  fork speed  PARP1  PARylation  replication stress  RECQ1  PrimPol  translesion synthesis
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