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Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Authors:Alba Luengo  Zhaoqi Li  Dan Y Gui  Lucas B Sullivan  Maria Zagorulya  Brian T Do  Raphael Ferreira  Adi Naamati  Ahmed Ali  Caroline A Lewis  Craig J Thomas  Stefani Spranger  Nicholas J Matheson  Matthew G Vander Heiden
Institution:1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;3. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;4. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA;5. Department of Biology and Biological Engineering, Chalmers University of Technology, SE412 96 Gothenburg, Sweden;6. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge CB2 0AW, UK;7. Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK;8. Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA;9. NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA;10. Dana-Farber Cancer Institute, Boston, MA 02115, USA
Abstract:
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  • Keywords:Aerobic Glycolysis  Cell Metabolism  NAD+  PDK  Fermentation  Warburg Effect
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