Uroporphyrinogen synthase in human blood: developmental studies. |
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Authors: | M Kreimer-Birnbaum |
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Institution: | Departments of Medicine and Biochemistry, State University of New York at Buffalo, Buffalo, N.Y. 14203, USA |
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Abstract: | Uroporphyrinogen synthase (URO-S), the enzyme that catalyzes the conversion of porphobilinogen to uroporphyrinogen I, has been measured in whole blood lysates by a fluorometric microassay. Cord and fetal bloods have 3 and 6 times the specific activity, respectively, of adult control subjects. The three groups seem to present a similar genetic heterogenity with ratios of highest to lowest URO-S specific activity close to 2. These results establish normal ranges for URO-S activity in human blood, which may be useful for the early detection of carriers of a gene for acute intermittent porphyria. |
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