Hypermotility induced by vasoactive intestinal peptide in the rat: its reciprocal action to cholecystokinin octapeptide |
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Authors: | S Itoh G Katsuura K Yoshikawa |
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Institution: | Shionogi Research Laboratories, Fukushima-ku, Osaka 553, Japan |
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Abstract: | Intracerebroventricular administration of vasoactive intestinal peptide (VIP) shortened the duration of pentobarbital-induced sleep and produced significant hypermotility in the rat. Although hypermotility induced by methamphetamine was not potentiated by central administration of VIP, L-DOPA-induced hypermotility in pargyline-pretreated rats was markedly enhanced by VIP and this hypermotility was suppressed by simultaneous administration of cholecystokinin octapeptide (CCK-8) in a dose-related manner. Apomorphine-induced hypermotility was also potentiated by VIP. These results suggest that VIP may stimulate postsynaptic dopaminergic receptor, causing an increase in motility, and that a possible reciprocal interaction exists between VIP and CCK-8. |
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Keywords: | Vasoactive intestinal peptide (VIP) Hypermotility Methamphetamine Apomorphine L-DOPA Dopaminergic system Cholecystokinin octapeptide |
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