Effects of GABA receptor stimulation on the release of [3H]GABA from slices of rat neostriatum. |
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| Authors: | D K Meyer U Conzelmann A Müller |
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| Institution: | Department of Pharmacology, University of Freiburg, F.R.G. |
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| Abstract: | Slices of rat neostriatum were incubated in Krebs-Henseleit medium. Modulation of 3H]GABA release by GABA agonists and antagonists was investigated. The GABAA receptor agonists muscimol (0.1 microM) and isoguvacine (5 microM) enhanced the stimulated release of 3H]GABA. The antagonists picrotoxin (1 microM) and bicuculline (50 microM) prevented the effects of the agonists. In the presence of naloxone (1 microM), which blocked the effects of enkephalinergic neurons within the slice preparation, muscimol (1 microM) no longer affected the release of 3H]GABA. |
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